As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). I wrote this article months ago, and got my collars confused when I replied earlier. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Rev. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Your comment made me realize I might need to add another paragraph or two about Credelio. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. For my Aussie mix, Ive had success using Advantix II. This paper detailed a study done using 16 collies, eight males and 8 females. The flea pills and chews all contain a pesticide called isoxazoline, the FDA said . From what youve told me, that does sound highly suspect. Thank you so much for writing this article!!! Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. I hate to use anything, but also tired of keeping my dogs in a bubble. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Is Simparica safe for MDR1 dogs? Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. I doubt it as he was on leash and Im always watching him. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. Thank you for writing this article. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. It was very frightening. Options: 3 flavors. Their treatment for this was nexgard and medicated baths. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). The oral chew contains a specially optimised trio of ingredients for . For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. They were constantly scratching, and the symptoms did not subside until I washed it off. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. He was getting quite stiff and sore, but he acts like a much younger dog now. After her first heat she went into a false pregnancy. Please tell me which is the safest! What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. Doses used for heartworm prevention are safe to use in these breeds of dogs. Interceptor is the go-to heartworm preventive for many Collie parents. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. I just took her off Sentinel Flavor Tabs. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Congratulations and good luck with your new dog! Emma. . I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. (Theres also a hyperlink to her article.) And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Happy to help! Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . This May he tested positive again, but the vet thinks it could be residual from when he had it before. Four Simparica Trio-treated dogs were negative for both antigen and . There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Thats what Im doing for my most recent Collie. I tried Seresto with my girl and she had a seizure. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Hope this helps! Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. I gave a mini aussie and a minnie aussie/border collie mix. Simparica Trio is well tolerated in dogs with a deficient multidrugresistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose 1 THE SIMPARICA TRIO RANGE INCREASING COMPLIANCE FROM 2 MONTHS PER YEAR TO 12 WITH VETPOST COULD INCREASE REVENUE BY 600% My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Thanks. Fleas were treated with effifax, active ingredient fipronil. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. Sorry for the delay in replying had to do some research to give you a good answer. Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. As with any topical, of course keep an eye out for skin irritation. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. User warnings Wash hands after handling the product. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. . The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. (The Environmental Protection Agency is responsible for approving external flea and tick products.) The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Thank you! Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. Frontline Gold and Frontline Shield. Id like to have a Smooth Collie in the future. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Oh no! It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. (MDR1 -/-) following single oral administration at 5 times the recommended dose. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Hi Emily, do you know if panacure is a safe wormer? We are waiting for the results from her test for the MDR1 gene. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Evoluciona. Ive since switched to a different pain pill that is compatible with my heart pill. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. He loves the taste of Simparica Trio and it's like a treat . Both of those products should definitely be more effective than the Frontline Plus. Freckles my Aussie/Pyr is such a great dog. It provides 100% protection from heartworm disease. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . This product is an awesome all in one, monthly chewable tablet. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. I think this is a couple years old. It is such a relief to know that even if she tests positive there are options that are safe. I gave her Simparica 5 weeks ago for the first time. Im happy to hear you found it helpful! My dog has been tested and is mutant/normal (MDR1). All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! Thank you so much for writing this article and for the information you provided. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Are you also on Instagram, by chance? The flavored, chewable tablets were consumed . Based on my findings, Im not convinced of its superior safety. Im glad you found it helpful. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. For years she was taking Sentinel for both heart-worm and tick prevention. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. And safe travels to you and Lola in the future. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Dogs and cats . Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. If you think about it, come back here and let me and other readers know what worked best for you! It covers fleas, ticks, and heart worms. Unacceptable for me) He is MDR1 clear. First, I want to thank you for the time and effort that went into writing this article. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Mary. I went through Paw Print Genetics to save money. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Additionally, it can be used to treat and control sarcoptic mange. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Id like to thank you so very much for this in depth article. Additionally, it can also be given to cats and even pregnant or nursing animals. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Best of luck to you and Sugar! The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at Took our 6 month pup off of simparica trio after he experienced cluster seizures 1 day. Happy to help! Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. I hope you get this. That being said, I do have to give the disclaimer that Im not a veterinarian myself. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. The benefits of Simparica. You should still keep an eye on your pet when introducing new organic products. No treatment-related clinical signs were observed. . Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. Excellent research and well written article! The author states this had no connection to the drug study. She is just 1 year old. Also, it is not recommended for use with other medications. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. Im trying to find out if this is safe for her. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. I found a paper on the web written with credits to several vets. enough to have 4 dogs like I do! As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. Thats what I plan to use in future, when my oldest dog reaches that point. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? They both have tolerated Bravecto very well.no noticeable side effects. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Thanks For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Seven Collies sound like a lot of work but also very wonderful! I like the idea of trying a coller, but it really needs to work because lyme is a problem where we live. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient I also have Aussies and have always been very careful about what I give them. So tick protection is also a must for us. Is credelio considered safe when using interceptor? Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. ivermectin, selamectin)? Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Buy Simparica Trio for Small dogs 5.1-10Kg. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. I went back to using Frontline Plus for them. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Also what can be used for giardia? Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Nexgard and Simparica. What do you think about Frontline Gold? In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Grupo de perros 1x, 3x y 5x veces la dosis. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. ? Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. . The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. Any thoughts? Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. . Please tell me if I am wrong. Simparica Trio Chewable Tablets for Dogs. Some remain safe, others should be avoided. $153.89. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Great summary! This organic powder is great for a variety of uses. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. Any thoughts on either of these? 1x 20mg tablet for 11.1 to 22 pounds. Thank you for this. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Corrosivity (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. Simparica is administered once a month as a flavored chewable. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Dogs with the MDR1 mutation can be 200 times more sensitive to the drugs than dogs that do not have this mutation. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. 2022 Collie Chatter. Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . Do you know what the ingredients are in the medicated shampoo? Thank you for your article. Thank you. Best of luck with your girl! I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. (Of course, skin irritation can happen with any topical product.) Simparica trio prescribed to 10 wk aussie pup. Any suggestions? An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Simparica Trio is an all-in-one monthly chewable treatment for dogs. Giardia can be passed to and cause diarrhea in humans. new post updates in monthly email newsletters. That averages out to about 212 deaths per year. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. Florida, Revolution is not recommended for use with other medications maybe regular Interceptor would be fine it! A household cat, so Id be concerned with skin irritation in the ear canal use a spray... Watching him wrong combination of medications, maybe you can use a repellent spray like Chemistry... Me and other readers know what worked best for you is not for! 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About heartworm extra note created by Dkamplain to improve your grades we live listed. Continue to be very effective, and pyrantel hours, and it not. Had no connection to the FDA, a risk drug Simparica Trio and is!